Things To Know About NADH Supplements For Chronic Fatigue Syndrome

People with chronic fatigue syndrome (CFS) often look for more effective ways to relieve their symptoms. You've heard about a supplement called NADH that is purported to reduce symptoms of this condition. Does it work? Should you give it a try? Research is scant, but some evidence does indicate that NADH helps a percentage of individuals dealing with CFS. 

About NADH

Nicotinamide adenine dinucleotide + hydrogen, commonly called NADH, is a form of vitamin B3 that occurs naturally in the body. The chemical is essential for energy generation, as it helps in the production of a chemical known as adenosine triphosphate, or ATP. ATP is the main molecule for energy storage and transport in cells. 

Because NADH has such an important role in cellular energy, a theory developed that consuming additional NADH may boost physical and mental energy. People take these products not only for CFS, but to improve their athletic performance, prevent jet lag, and boost concentration, memory and mental clarity. 

Relevant Research

A study published in 1999 found that 8 of 26 participants with CFS, or 31 percent, had good results with the supplements. They took 10 mg per day for four weeks. Thus, not everyone with CFS responds to NADH, but it can be a welcome addition to a health care regimen for those who experience positive effects. 

A review of studies that appeared in 2011 noted that research has only found two supplements with positive effects for CFS patients: NADH and magnesium. 


NADH supplements are generally considered safe and don't cause side effects as long as people buy them from a reputable manufacturer and don't exceed the maximum recommended dosage on the label. If you're taking prescription medication for CFS or another condition, tell your health care provider before you add NADH to your supplement routine.

How to Take NADH

Follow the directions on the label, which typically advise taking the supplement with water on an empty stomach. Health care providers usually suggest starting with the lowest recommended dosage and increasing the dose if you don't experience results within the expected time frame. You may want to follow the 1999 study parameters.  

It's possible to develop a tolerance to NADH supplements. Take a break for a week or two after 12 weeks. Don't increase the dose beyond the maximum in an effort to continue experiencing positive effects.

These products are available from many stores and online suppliers. Consider giving the supplements a try to see whether they are effective for reducing your chronic fatigue.